Potassium Ion Movement in the Inner Ear: Insights from Genetic Disease and Mouse Models
Identifieur interne : 000A40 ( Main/Exploration ); précédent : 000A39; suivant : 000A41Potassium Ion Movement in the Inner Ear: Insights from Genetic Disease and Mouse Models
Auteurs : Anselm A. Zdebik [Royaume-Uni] ; Philine Wangemann [États-Unis] ; Thomas J. Jentsch [Allemagne]Source :
- Physiology (Bethesda, Md.) [ 1548-9213 ] ; 2009.
Abstract
Sensory transduction in the cochlea and vestibular labyrinth depends on fluid movements that deflect the hair bundles of mechanosensitive hair cells. Mechanosensitive transducer channels at the tip of the hair cell stereocilia allow K+ to flow into cells. This unusual process relies on ionic gradients unique to the inner ear. Linking genes to deafness in humans and mice has been instrumental in identifying the ion transport machinery important for hearing and balance. Morphological analysis is difficult in patients, but mouse models have helped to investigate phenotypes at different developmental time points. This review focuses on cellular ion transport mechanisms in the stria vascularis that generate the major electrochemical gradients for sensory transduction.
Url:
DOI: 10.1152/physiol.00018.2009
PubMed: 19815857
PubMed Central: 4415853
Affiliations:
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Zdebik</name><affiliation wicri:level="3"><nlm:aff id="A1">UCL, Department of Neuroscience, Physiology, and Pharmacology, and Department of Medicine, London Epithelial Group, Hampstead Campus, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL, Department of Neuroscience, Physiology, and Pharmacology, and Department of Medicine, London Epithelial Group, Hampstead Campus, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Wangemann, Philine" sort="Wangemann, Philine" uniqKey="Wangemann P" first="Philine" last="Wangemann">Philine Wangemann</name><affiliation wicri:level="2"><nlm:aff id="A2">Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kansas</region></placeName><wicri:cityArea>Anatomy and Physiology Department, Kansas State University, Manhattan</wicri:cityArea></affiliation></author><author><name sortKey="Jentsch, Thomas J" sort="Jentsch, Thomas J" uniqKey="Jentsch T" first="Thomas J." last="Jentsch">Thomas J. 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Jentsch</name><affiliation wicri:level="3"><nlm:aff id="A3">Leibniz-Institut für Molekulare Pharmakologie (FMP) and Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz-Institut für Molekulare Pharmakologie (FMP) and Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j">Physiology (Bethesda, Md.)</title><idno type="ISSN">1548-9213</idno><idno type="e-ISSN">1548-9221</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Sensory transduction in the cochlea and vestibular labyrinth depends on fluid movements that deflect the hair bundles of mechanosensitive hair cells. Mechanosensitive transducer channels at the tip of the hair cell stereocilia allow K<sup>+</sup> to flow into cells. This unusual process relies on ionic gradients unique to the inner ear. Linking genes to deafness in humans and mice has been instrumental in identifying the ion transport machinery important for hearing and balance. Morphological analysis is difficult in patients, but mouse models have helped to investigate phenotypes at different developmental time points. 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Zdebik</name></region></country><country name="États-Unis"><region name="Kansas"><name sortKey="Wangemann, Philine" sort="Wangemann, Philine" uniqKey="Wangemann P" first="Philine" last="Wangemann">Philine Wangemann</name></region></country><country name="Allemagne"><region name="Berlin"><name sortKey="Jentsch, Thomas J" sort="Jentsch, Thomas J" uniqKey="Jentsch T" first="Thomas J." last="Jentsch">Thomas J. Jentsch</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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